Herbicidal properties of antihypertensive drugs: calcium channel blockers

Abstract Herbicide resistance is a worldwide problem in weed control. This prompts researchers to look for new modes of action slow down the evolution herbicide-resistant weeds. research aims determine herbicidal thiazolo[3,2-a]pyrimidines derivatives, which are well known as antihypertensive drugs. The phytotoxic effects ten compounds were investigated using leaf disc discoloration test and seed germination bioassay. At concentrations 125 250 mg/L, 5-(3-Fluoro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester ( c ) was highly active against Oldenlandia verticillata Eleusine indica . application rates 1.25 2.5 kg ai/ha, formulated demonstrated selective post-emergence pre-emergence activity O. , E. Cyperus iria In crop tolerance test, outperformed commercial herbicide diuron, with aerobic Oryza sativa being most tolerant, followed by Zea mays Brassica rapa addition calcium chloride partially nullified compound 's inhibitory on shoot growth, indicating that it has potential channel blocker. Compound acted triggering electrolyte leakage without affecting photosystem II. These findings imply could be explored further template developing herbicides novel action.